Compared with chronic carriers, HCC patients had a significantly higher frequency of BCP T1762/A1764 mutants (77.7 vs. 21.2%, P = 0.0001; Table 3), and a higher frequency of PC A1896 mutants (46.0 vs. 30.2%, P = 0.04). Here, OPN1SW is linked to hepatocellular carcinoma.