Logistic regression analysis revealed that BCP T1762/A1764 mutants [odds ratio (OR) 11.14, 95% confidence interval (CI) 3.05–40.72; P < 0.001] and PC A1896 mutants (OR 3.75, 95% CI 1.14–12.34; P < 0.05) were significantly associated with HCC development. This evidence concerns the gene OPN1SW and hepatocellular carcinoma.