By univariate analysis, older age (P = 0.002), male gender (P = 0.001), HBV genotype C (P = 0.0003), PC A1896 mutants (P = 0.04) and BCP T1762/A1764 mutants (P = 0.0001) were significantly associated with HCC (Table 3). Here, OPN1SW is linked to hepatocellular carcinoma.