Also, compared with chronic carriers, higher numbers of PC wild-type sequences plus BCP T1762/A1764 mutant sequences (44.7 vs. 12.8%), and more PC A1896 mutant sequences plus BCP T1762/A1764 mutant sequences were detected in HCC patients (32.9 vs. 8.5%, P = 0.001 for all observations). The gene discussed is OPN1SW; the disease is hepatocellular carcinoma.