siRNA-mediated DVL knockdown blocked proliferation of human breast cancer cells by 20% to 60% 7 days after transfection as determined by cell counting after viability staining (Figure 3a), with the most prominent effect in JIMT-1, SkBr3, and MDA-MB-231 cells, whereas BT474 and MCF-7 cells are less affected. This evidence concerns the gene DVL1 and breast carcinoma.