AGTR2 and hypertensive disorder: For example, if the doctor of a patient with uncomplicated hypertension does not realize the large price difference between the high- and low-cost products (e.g., in the province of Ontario the daily cost for hydrochlorothiazide, a thiazide diuretic, is CAN$0.01 versus CAN$1.05 for valsartan, an angiotensin 2 receptor antagonist), she or he may prescribe the more-expensive agent.