Overexpression of SOD2 in deficient cell lines has reduced the proliferation of pancreatic carcinoma cells (Weydert et al, 2003; Ough et al, 2004), multiple myeloma cells (Hodge et al, 2005b), glioma cells (Zhong et al, 1997), squamous oral carcinoma cells (Liu et al, 1997), and prostate carcinoma cells (Li et al, 1998b; Zhong et al, 2004; Venkataraman et al, 2005). The gene discussed is SOD2; the disease is plasma cell myeloma.