Similarly to the tumour grade and mitotic index indicated above, most of the cases with a tumour size between 2 and 5 cm (84.3%) and more than 5 cm (92.3%) over expressed Her-2 (p < 0.0001) and were ER negative (80.9% and 88.5% respectively, p < 0.0001). Here, ERBB2 is linked to neoplasm.