Our results showed that over expression of Her-2 and lack of ER expression were mostly seen with stages III and IV, whereby 81.2% and 85.4% of stage III tumours over expressed Her-2 and were ER negative respectively (p < 0.0001), and 87.5% and 75% of stage IV tumours over expressed Her-2 and were ER negative respectively (p < 0.0001). The gene discussed is ERBB2; the disease is neoplasm.