Furthermore, both Angiotensin II, which produces vasoconstriction and mucosal ischemia, and RMCP-II, which increases intestinal permeability and enhances antigen and bacteria uptake, consequently induce bacterial translocation to the mesenteric lymph nodes where they would activate a "chemotactic call" to mast cells and worsen the inflammatory responses [60]. This evidence concerns the gene AGT and ischemia.