Importantly, also, SERMs could interfere with survival pathways known to be constitutively activated in MM such as Janus Kinase (JaK)/STAT3 [40,41], NF-κB (nuclear factor-κB) [42,43] and Ras/MAPK (mitogen-activated protein kinase) [44,45]. Here, STAT3 is linked to Miyoshi myopathy.