TNFRSF1A and breast carcinoma: Tamoxifene- or ICI-induced breast cancer cells apoptosis is associated with the increase of tumor necrosis factor receptor 1 (TNFR1) [26], the activation of caspase-3 and c-jun NH2-terminal kinase-1 (JNK) [25] or the extracellular signal-regulated kinase (ERK) [27] signaling pathways, or an increase in the production of oxygen reactive species [28].