It is also interesting to note that G2 contained an "integral to plasma membrane" component consisting of the well known DLBCL relevant pathway – G-protein coupled receptor protein signalling pathway (e.g. LANCL1, CASC1 and PIK3CG) [29] and JAW1 for vesicle targeting and homocyte development. This evidence concerns the gene IRAG2 and diffuse large B-cell lymphoma.