The results showed that the values of SEP were significantly dependent on ER status (positive vs. negative), PR status (positive vs. negative), tumor size (T1 vs. T2) and histological grade (1 vs. 2 vs. 3) with p < 0.001, but not on angioinvasion (positive vs. negative, p = 0.21) or age of patients (<= 40 vs. >40, p = 0.61). This evidence concerns the gene ESR1 and neoplasm.