Two recent studies have shown that both the CYT-1 isoform and JM-a isoform are overexpressed in the dorsolateral frontal cortex of schizophrenic patients and suggest that dysregulated splice variant expression of Erbb4 may underlie the genetic association of Erbb4 with schizophrenia [77,78]. Here, ERBB4 is linked to schizophrenia.