For example, in Spain, a large multicenter, outpatient clinics cross sectional population study, on hypertensive and type 2 DM patients, evaluating the risk of cardiovascular disease and renal damage using ECG-LVH, GFR and/or urinary albumin excretion, was able to establish an increased prevalence of cardiovascular disease in patients with hypertension and type 2 DM [15]. This evidence concerns the gene ALB and hypertensive disorder.