TRAF1 and rheumatoid arthritis: Haplotypes were predicted, and analyses from all blocks revealed that the association with RA was restricted to SNPs in block 2 (Figure 1B), as demonstrated by the global p-value of association (p < 0.05) and suggesting the possible involvement of TRAF1 and/or the 3′ end of C5. Of the four common haplotypes capturing > 95% of the variation, two significantly associated haplotypes were observed, one increased in RA patients (susceptible haplotypebp = 0.039), and one over-represented in controls (protective haplotypeap = 0.012).