TRAF1 and rheumatoid arthritis: Single SNP analysis performed in the first set of RA patients (n = 290) and controls (n = 254) revealed significant association between six SNPs in the TRAF1/C5 region (SNPs 4, 7, 10, 14, 15, and 16) and RA (p = 0.0104, 0.0153, 0.0080, 0.0039, 0.0039, and 0.0250, respectively) (Table 1).