It is biologically plausible that ADAM33 is relevant to the development of psoriasis because it may be involved in the inflammatory response, or in cell-cell and cell-matrix interactions that are essential for the development and maintenance of a tissue; likewise, extracellular matrix proteolysis is an important contributor to skin remodeling, which when altered might ultimately lead to significant desquamation or, perhaps, absence of cell maturation. This evidence concerns the gene ADAM33 and psoriasis.