We recently discovered that DFO inhibited the proliferation and induced the apoptosis of immortalized human oral keratinocytes (IHOK) and oral cancer cells [27] We also reported that p38 and ERK MAP kinase mediated DFO-induced apoptosis and the suppression of differentiation in IHOK and oral cancer cells [28]; however, an immunomodulatory role of IL-8 against the iron chelator DFO has not been reported in oral cancer and IHOK cells. This evidence concerns the gene CXCL8 and lip and oral cavity carcinoma.