It has been demonstrated that the homeostasis model assessment insulin resistance index HOMA-IR (computed as the product of the fasting values of glucose, expressed as mM, and insulin, expressed as μU/mL, divided by the constant 22.5) [47-49], its reciprocal insulin sensitivity index 1/HOMA-IR [50], and the quantitative insulin sensitivity check index QUICKI [51] are useful surrogate indices of insulin resistance because of their high correlation with the index assessed by the euglycemic hyperinsulinemic clamp [11]. This evidence concerns the gene INS and Insulin resistance.