IFNγ induces expression of p47 GTPases via activation of Stat1 which was also increased by Salmonella at days 2 and 3 p.i. Mutant mice with gene disruptions in IFNγ or Stat1 are significantly compromised in their immune response to microbial infections, including salmonellosis [41]. The gene discussed is STAT1; the disease is salmonellosis.