The results of our study and the high frequency of ENPP1 K121Q in humans [26] support the view that among the various described mechanisms of insulin resistance mediated by defective adipogenesis, such as in lipodystrophy models [27], [28], in defective PPAR-γ function [29], and in Pref-1 overproduction [30], ENPP1 expression and its K121Q variant are likely to explain a large portion of the “garden variety” insulin resistance we find in people at relatively low body mass index (BMI). Here, PPARG is linked to lipodystrophy.