The replacement method was used for the other proteins that have rather irregular shape, including interfacial peptides, such as PDB:1H2S (sensory rhodopsin II), 2A65 (a bacterial homolog of Na+/Cl− dependent neurotransmitter transporters), 1SU4 (calcium ATPase), 1PHO (E. Coli porins), 1XQ8 (human micelle-bound alpha-synuclein), 2DEO (membrane protease specific for a stomatin homolog from Pyrococcus horikoshii), PDB:1UUN (main porin from Mycobacteria), and 1D5R (PTEN tumor suppressor). The gene discussed is VDAC1; the disease is neoplasm.