Several studies including a meta-analysis of 12 studies have demonstrated that TGFBR1*6A acts as a low-penetrance tumour susceptibility allele in the development of colon, cervix, breast, and ovarian cancer as well as haematological malignancies (Chen et al, 1999; Pasche et al, 1999, 2004; Baxter et al, 2002; Kaklamani et al, 2003; Bian et al, 2005; Kaklamani and Pasche, 2005). This evidence concerns the gene TGFBR1 and neoplasm.