TGFBR1 and neoplasm: Two common alleles in the TGFBR1 gene, TGFBR1*6A and Int7G24A, A allele, which reside in exon 1 and intron 7, respectively, have been reported to act as low-penetrance tumour susceptibility alleles (Chen et al, 1999, 2004, 2006; Pasche et al, 1999, 2004; Baxter et al, 2002; Kaklamani et al, 2003; Zhang et al, 2003; Bian et al, 2005; Kaklamani and Pasche, 2005).