In addition, group 2 showed a significantly higher percentage of tumours positive for TIMP-1, MMP-9 and -11 in the tumour cells; as well as a significantly higher percentage of tumours positive for TIMP-2, TIMP-3, MMP-9, -11, -13 and -14, in fibroblastic cells (Table 2). The gene discussed is TIMP1; the disease is neoplasm.