Matrix metalloproteinase-1 was immunohistochemically detected in 88.3% of breast carcinomas, MMP-2 in 42%, MMP-7 in 87.4%, MMP-9 in 74%, MMP-11 in 89.3%, MMP-13 in 73.3%, MMP-14 in 90%, TIMP-1 in 95%, TIMP-2 in 87% and TIMP-3 in 82.3%. This evidence concerns the gene TIMP2 and breast carcinoma.