Neoangiogenesis depends on the interplay of different members of the VEGF and Ang family, and many of these factors that are present in significant amounts in the marrow environment may function in a synchronised fashion in addition to any local autocrine or paracrine effects they may have; therefore, comprehensive analyses on marrow levels of these factors in AML patients and the clinical implications of these levels are important and remain to be explored. Here, ANG is linked to acute myeloid leukemia.