TEK and acute myeloid leukemia: Recently, Schliemann et al (2006) used an immunohistochemical stain to study BM biopsy samples and discovered that both Ang-2 and Tie-2 were overexpressed in the leukaemic blasts of AML patients; however, Ang-1 was not Loges et al (2005) employed quantitative RT–PCR to study mRNA expression and discovered that the median levels of VEGF-A, VEGF-C, Ang-1, and Ang-2 were higher in PB blasts than in normal PB AC133+ cells.