Higher levels of HK, namely, HK2 (Torizuka et al, 1995; Mathupala et al, 1997) and GLUT, especially GLUT1 (Mueckler, 1994; Younes et al, 1996; Smith, 1999) and low levels of G-6-Pase (Nelson et al, 1996) have been reported in tumour tissue compared with corresponding normal tissue. This evidence concerns the gene G6PC1 and neoplasm.