EGFR and non-small cell lung carcinoma: Gefitinib (‘Iressa’, AstraZeneca) is a small molecule and selective EGFR tyrosine kinase inhibitor (EGFR-TKI) that has shown antitumour activity in NSCLC patients as a single agent in phase II and III trials (Fukuoka et al, 2003; Thatcher et al, 2005).