HOXA1 and Bosley-Salih-Alorainy syndrome: Knockout studies on other vertebrates showed that a complete knockdown for paralogy group 1 in Xenopus results in serious developmental defects [91], and mutations in HoxA1 in humans are linked with Bosley-Salih-Alorainy syndrome effecting delayed development, eye movement and formation of the cranial nerve VIII [92].