Three categories had median P values below 0.001 (FDR = ~0): breast cancer estrogen signaling; MSigDB's set of ER-upregulated genes identified by Frasor and coworkers [33]; and drug resistance and metabolism, which contains ESR1, BCL2, AR and ER's co-regulator ERBB4 [34]. Here, ERBB4 is linked to breast carcinoma.