A population-based study in Finland reported that the prevalence of asthma increased gradually with increasing serum CRP concentration.10 Inflammation in the respiratory tract is thought to play an important role in the pathological conditions of wheezing and asthma.30 Wheezing is often caused by a viral infection.31 In the present study, the serum CRP concentration was slightly higher in children with asthma than those without, but the difference was not significant, possibly because most asthmatic children were asymptomatic when examined. This evidence concerns the gene CRP and viral infectious disease.