Thus, a posible neuroprotective role of sGAG in Alzheimer's disease could not be excluded, and the neuroprotective role could be extended to some related compounds like 3-APS, because 3-APS could be used for decreasing Aβ pathology and, although it aggregates tau protein, it is not toxic for cultured cells. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.