It has been proposed that some compounds like sulfated glycosaminoglycans (sGAG) [2] could promote the aggregation of Aβ and tau [3-5], and it has been even suggested that in Alzheimer's disease sGAG may provide a common link for Aβ and tau polymerization [3-8]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.