Gastric cancer cells are often characterized by overexpression of Dnmt1 with hypermethylation of genes relevant to the etiology of gastric cancer, including human MutL homologue 1 (hMLH1), thrombospondin-1 (THBS-1), and E-cadherin (Etoh et al. 2004). The gene discussed is MLH1; the disease is gastric cancer.