In addition, NF-κB–dependent Fas transcription is down-regulated by the suppressive action of c-Jun and STAT3 in human melanoma-derived cell lines [16], and NF-κB bound to the Il6 and Il12b promoters is gradually replaced by ATF3, which interacts with AP-1 and STAT [17]. This evidence concerns the gene NFKB1 and melanoma.