GSK3B and cleidocranial dysplasia 1: Here again, the lithium chloride administration succeeded in restoring both fontanelle and clavicle abnormalities in the Runx2+/− mice, similarly to the genetic rescue in the Gsk-3β+/−; Runx2+/− mice (Fig. 5C, D), raising the possibility that pharmacological intervention such as lithium chloride administration may clinically be useful for preventing cleidocranial dysplasia.