Here again, the lithium chloride administration succeeded in restoring both fontanelle and clavicle abnormalities in the Runx2+/− mice, similarly to the genetic rescue in the Gsk-3β+/−; Runx2+/− mice (Fig. 5C, D), raising the possibility that pharmacological intervention such as lithium chloride administration may clinically be useful for preventing cleidocranial dysplasia. Here, RUNX2 is linked to cleidocranial dysplasia 1.