Interestingly, Sp1 is involved in the regulation of several genes which have been implicated in schizophrenia such as reelin, GAD67, MAOA/B, NMDA receptor subunits NR1 and NR2A/B, GABA A and DA receptors D1A and D2/3 [19]–[24]. The gene discussed is SP1; the disease is schizophrenia.