Mithramycin induced a time dependent decrease in mRNA and protein levels of complex I subunits NDUFV1, NDUFV2 and NDUFS1, as well as of reelin, which was arbitrarily chosen as a gene known to be modulated by Sp1 and repeatedly reported to be abnormally expressed in schizophrenia [19], [50]. The gene discussed is SP1; the disease is schizophrenia.