PCM1 and neoplasm: Several candidate tumor suppressor genes have been identified from 8p including DLC-1 (8p21.3-22) [41], FEZ1 (8p22) [42], liver-related putative tumor suppressor (LTPS) gene (8p23) [43], PCM1(encoding a centrosomal protein) and DUSP4/MKP-2 (encoding a MAP kinase phosphatase) [44].