Recent immunological studies revealed that Ab directed to a panel of sporozoites and pre-erythrocytes antigens (NANP10, TRAP, SALSA, GLURP, STARP) or crude schizont extract increased with malaria exposure [17,18]; these Ab responses, therefore, estimate the level of malaria transmission rather than an immune-dependent protection [19]. The gene discussed is DMBT1; the disease is malaria.