Furthermore, tissue-specific Perk ablation in the entire pancreas (pcPKO, using Pdx1-Cre) causes both diabetes and exocrine atrophy; by contrast, mice with gene deletion only in islets (enPKO, using Ngn3-Cre) exhibit diabetes without exocrine atrophy [11]. The gene discussed is EIF2AK3; the disease is diabetes mellitus.