LPL and hyperkeratosis lenticularis perstans: Since LPL SNPs are associated with triglycerides in our patients who are not APOE2/2 this implies that the triglyceride raising effect of the N291S variant, 30%, and the lowering effect of the S447X variant, 8%, are masked by the other genetic and environmental factors contributing to the development of Type III HLP in APOE2/2 patients.