Conversely, AXUD1/CSRNP-1 has been shown to be down-regulated in microarray studies in a variety of tumors including lung, liver, colon and kidney cancers [18], intrahepatic cholangiocarcinomas [27], pancreatic tumors [28] and breast cancers [29]. The gene discussed is CSRNP1; the disease is intrahepatic cholangiocarcinoma.