Elevated PLD activity was found in 17 out of 19 microsomal preparations from human breast tumours as compared to microsomal preparations from adjacent normal breast tissue (Uchida et al, 1997) and PLD mRNA and protein levels were overexpressed in 14 of 17 breast cancer tissues compared to normal (Noh et al, 2000). The gene discussed is GPLD1; the disease is breast cancer.