This induces the activation of integrins on CXCR4-expressing breast cancer cells which causes transendothelial migration of the cells followed by growth and angiogenesis resulting in secondary tumours (Beckmann et al, 1997; Murphy, 2001; Kucia et al, 2004; Luker and Luker, 2006). This evidence concerns the gene CXCR4 and neoplasm.