In a recent report, we have shown that another chemopreventive agent curcumin inhibited the expression of antiapoptotic Bcl-2 and Bcl-XL, and induced the expression of proapoptotic Bax, Bak, PUMA, Noxa, and Bim in prostate cancer cells [53]. The gene discussed is PMAIP1; the disease is Familial prostate cancer.