In East Asians, in whom the ADH1B*2 allele is found at high frequency, it is protective against alcoholism (Chen et al. 1999a; Crabb et al. 2004; Hurley et al. 2002; Luczak et al. 2006; Thomasson et al. 1991; Whitfield 2002). This evidence concerns the gene ADH1B and alcohol drinking.