Figure 2 show the level of expression of E2F1, RUNX3, EGR3, TBPIP, ECM2, ESM1, THBS1, GAS1, ADAM17, CST6, CST7, FBLN5, ICAM2, EDN1 and COL18, representing transcription factors, cell cycle and apoptosis regulators, matrix remodeling and cell adhesion signaling, respectively in matched leiomyoma and myometrium from African Americans and Caucasians. This evidence concerns the gene ADAM17 and leiomyoma.