Among these genes involved in these processes are collagens, versican, fibromodulin, syndecan 4, TSP-1, tenascin-C, osteonectin/SPARC and ECM2, endothelial cell specific molecule-1 (ESM-1), ICAM2, EDN1, FZD7, β1 catenin, CST6, CST7 as well as several member of integrins, MMPs, TIMPs and ADAMs [44-49] that are expressed in leiomyomas [7,26,27] with altered expression in African Americans. Here, SPARC is linked to leiomyoma.