THBS1 and leiomyoma: Plasmin, integrins, thrombospondin-1 (TSP-1), mannose 6-phosphate, and decorin are known to activate TGF-β [32-34] and their differential expression suggests the presence of regulatory mechanism that control TGF-β action in leiomyoma where it regulates the expression of several genes involved in tissue fibrosis [19,25-28,35].