CNR1 and cancer: This concept might be exploited for the treatment of endocannabinoid-related diseases that are CB1R-dependent, such as brain injury (Mechoulam et al., 2002) and oxidative stress (Carracedo et al., 2004), cancer (Guzman, 2003), and neurodegenerative disorders (Piomelli, 2003; Maccarrone et al., 2007).