CNR1 and neoplasm: Since several human glioblastoma tumors possess CAV1 (Cameron et al., 2002), and depletion of cholesterol in lipid rafts has been shown to inhibit apoptosis induced by anti-tumor drugs (Gajate and Mollinedo, 2001), this investigation raises the suggestive although still speculative idea that perturbation of lipid rafts, by modulating CB1R- and CAV1-dependent signaling, may be involved in finely tuning cell survival and death within the central nervous system.