This observation suggests a strong link between CB1R and CAV1, that seems interesting because caveolae play a role in neurodegenerative diseases, like Parkinson's disease, Alzheimer's disease and dementia with Lewy's bodies (Hashimoto et al., 2003), as well as in other neurological abnormalities (Trushina et al., 2006). The gene discussed is CNR1; the disease is Alzheimer disease.