In multivariate analysis, two factors were associated with the occurrence of HIV infection or death (n = 231): low birth weight (adjusted hazard ratio = 3.71 [95% CI 1.53–9.03], p = 0.004) and female sex (adjusted hazard ratio = 0.35 [95% CI 0.14–0.88], p = 0.035), after controlling for infant feeding practice, maternal ARV drug regimen, WHO staging, absolute CD4 T count, haemoglobin level, and age at baseline. This evidence concerns the gene CD4 and HIV infectious disease.