Eight women (7.5%) developed grade 3 or 4 adverse events attributed to HAART: five women developed grade 3 mucocutaneous rash attributed to NVP and were switched to nelfinavir, and two women developed grade 4 liver toxicity attributed to NVP, with alanine aminotransferase levels over 50 times and over 5 times the upper limit of normal value, respectively in the two groups of women; one woman developed severe anaemia attributed to ZDV. The gene discussed is GPT; the disease is anemia (phenotype).