The finding of homeodomain dependent induction of Jag2 by ND13 and NA10 in Sca1+, Lin− BM cells, and that JAG2 expression correlated with HOXA7 and HOXA9 expression in AML samples is also very interesting since JAG2 was recently found to be overexpressed in CD34(+)CD38(−) isolated leukemic stem cells from AML patients [47]. This evidence concerns the gene CD38 and acute myeloid leukemia.