Predominating biochemical pathways found to be significantly over-represented in TGCT cells were angiogenesis, Wnt signaling pathway, inflammation mediated by chemokine and cytokine signaling pathway, integrin signalling pathway, PDGF signaling pathway, interleukin signaling pathway, Huntington disease, Alzheimer disease-presenilin pathway, cadherin signaling pathway, p53 pathway, TGF-beta signaling pathway, and apoptosis signaling pathway. Here, CDH17 is linked to early-onset autosomal dominant Alzheimer disease.