Remarkably, whereas S. pneumoniae PLN did not further grow in the lungs of WT mice from 24 h after infection onward, which is in line with a previous investigation (Canvin et al., 1995), the bacterial load increased more than 10-fold in lungs of TLR2 KO mice between 24 and 72 h after inoculation. The gene discussed is TLR2; the disease is infection.