TLR2 and infection: A limited role for TLR2 during infection with WT S. pneumoniae is further supported by a recent study in which intact pneumococci were administered intraperitoneally (Khan et al., 2005), although TLR2 KO mice displayed a modestly slower clearance of S. pneumoniae from their nasopharynx in another investigation (van Rossum et al., 2005).