PPARA and pulmonary fibrosis: The role of PPARα in lung fibrosis was investigated in miceusing the bleomycin model of lung injury and fibrosis.Intratracheal instillation of the antineoplastic agent bleomycincauses acute lung inflammation that develops into severe fibrosis,with proliferation of α-SMA-positive myofibroblasts,increased collagen deposition, and loss of normal alveolararchitecture [48, 49].