Several studies have suggested a potential role for PPARγin the pathogenesis of pulmonary hypertension.For example, PPARγ is abundantlyexpressed in pulmonary vascular endothelial cells of normal human lung tissueand is significantly reduced in the plexiform lesions of human subjects withpulmonary hypertension [111]. The gene discussed is PPARG; the disease is pulmonary arterial hypertension.