In the meta-analysis by Mirza et al. [19], studies with sample size more than 200 and follow-up more than 5 years were evaluated and tumor size, tumor grade, cathepsin-D, Ki-67, S-phase fraction, mitotic index, and vascular invasion were found to be associated with survival outcome in patients with early-stage node-negative breast cancer. This evidence concerns the gene CTSD and neoplasm.