We have determined the frequency of 5 polymorphisms in 4 different genes implicated in DNA damage repair (XPC PAT, XPD Asp312Asn, XPD Lys751Gln, XRCC1 Arg399Gln, and XRCC3 Thr241Met) in lung cancer patients and matched controls in order to evaluate their association with the risk of lung cancer. The gene discussed is XPC; the disease is lung cancer.