The presence of the variant alleles 312Asn and 751Gln of XPD have been associated with relatively high risk of lung cancer in Caucasian [17-20] and Asian [21-24] populations and a recent meta-analysis concludes that the variant genotypes 312Asn/Asn and 751Gln/Gln are associated with a statistically significant lung cancer risk in the Caucasian population [25]. The gene discussed is ERCC2; the disease is lung carcinoma.