Our results support that polymorphisms in two different NER genes (XPC and XPD) increased the risk of developing lung cancer, so individuals homozygous for the XPC PAT+, XPD 312Asn or XPD 751Gln alleles have a higher risk of developing lung cancer (ORs 1.28, 1.52 and 1.38, respectively). The gene discussed is ERCC2; the disease is lung cancer.