Those individuals homozygous for the XPD polymorphisms (312Asn/Asn and 751Gln/Gln) presented a not statistically significant higher risk of developing lung cancer (adjusted OR = 1.52; 95% CI = 0.91–2.51, P = 0.106; adjusted OR = 1.38; 95% CI = 0.85–2.25, P = 0.193, respectively). This evidence concerns the gene ERCC2 and lung cancer.